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Primed histone demethylation regulates shoot regenerative competency
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Journal Article
Primed histone demethylation regulates shoot regenerative competency
2019
Overview
Acquisition of pluripotency by somatic cells is a striking process that enables multicellular organisms to regenerate organs. This process includes silencing of genes to erase original tissue memory and priming of additional cell type specification genes, which are then poised for activation by external signal inputs. Here, through analysis of genome-wide histone modifications and gene expression profiles, we show that a gene priming mechanism involving
LYSINE-SPECIFIC DEMETHYLASE 1-LIKE 3 (LDL3)
specifically eliminates H3K4me2 during formation of the intermediate pluripotent cell mass known as callus derived from
Arabidopsis
root cells. While LDL3-mediated H3K4me2 removal does not immediately affect gene expression, it does facilitate the later activation of genes that act to form shoot progenitors when external cues lead to shoot induction. These results give insights into the role of H3K4 methylation in plants, and into the primed state that provides plant cells with high regenerative competency.
Plant regeneration can occur via formation of a mass of pluripotent cells known as callus. Here, Ishihara et al. show that acquisition of regenerative capacity of callus-forming cells requires a lysine-specific demethylase that removes H3K4me2 to prime gene expression in response to regenerative cues.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 14
/ 14/19
/ 38
/ 38/91
/ 45
/ 45/15
/ 631/136
/ 631/449
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Callus
/ Epigenesis, Genetic - physiology
/ Gene Expression Regulation, Plant - physiology
/ Genes
/ Genomes
/ Histone Demethylases - genetics
/ Histone Demethylases - metabolism
/ Humanities and Social Sciences
/ Lysine
/ Organs
/ Plants, Genetically Modified
/ Priming
/ Protein Processing, Post-Translational - physiology
/ Science
