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Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster
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Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster
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Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster
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Journal Article
Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster
2022
Overview
Many vital processes in the eye are under circadian regulation, and circadian dysfunction has emerged as a potential driver of eye aging. Dietary restriction is one of the most robust lifespan-extending therapies and amplifies circadian rhythms with age. Herein, we demonstrate that dietary restriction extends lifespan in
Drosophila melanogaster
by promoting circadian homeostatic processes that protect the visual system from age- and light-associated damage. Altering the positive limb core molecular clock transcription factor, CLOCK, or CLOCK-output genes, accelerates visual senescence, induces a systemic immune response, and shortens lifespan. Flies subjected to dietary restriction are protected from the lifespan-shortening effects of photoreceptor activation. Inversely, photoreceptor inactivation, achieved via mutating rhodopsin or housing flies in constant darkness, primarily extends the lifespan of flies reared on a high-nutrient diet. Our findings establish the eye as a diet-sensitive modulator of lifespan and indicates that vision is an antagonistically pleiotropic process that contributes to organismal aging.
Circadian dysfunction is a potential driver of eye aging. Here the authors report that in conjunction with the core molecular clock transcription factor Clock, dietary restriction promotes rhythmic homeostatic mechanisms within photoreceptors to delay visual senescence and extend lifespan in
Drosophila Melanogaster
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/61
/ 38/88
/ 38/89
/ 38/91
/ 64/24
/ 9/30
/ 96/63
/ Aging
/ Animals
/ Darkness
/ Diet
/ Drosophila melanogaster - genetics
/ Drosophila Proteins - genetics
/ Eye
/ Flies
/ Housing
/ Humanities and Social Sciences
/ Insects
/ Science
