Asset Details
Do you wish to reserve the book?
Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation
Do you wish to request the book?
Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation
2018
Overview
Background
This study evaluated the effect of radiation dose rate in patients with hematolymphoid malignancies undergoing myeloablative conditioning with total body irradiation (TBI), for hematopoietic stem cell transplantation.
Methods
The incidence of pulmonary toxicity (PT) and treatment efficacy were compared between the conventional (≥ 6 cGy/min) and reduced dose rate (< 6 cGy/min). Seventy-seven patients receiving once-daily TBI between 2000 and 2016 were reviewed. We compared the cumulative rate of PT, overall survival (OS), relapse, and transplantation-related mortality (TRM) between conventional (
n
= 54) and reduced (
n
= 23) groups. Factors associated with PT were assessed in the presence of competing risks.
Results
The median follow-up time was 40.7 months, and PT occurred in 50 patients (64.9%). On multivariate analyses, the groups classified by the dose rate (
P
= 0.010), total dose (
P
= 0.025), and conditioning regimen (
P
= 0.029) were significant factors for the development of PT. OS was significantly reduced when PT occurred (
P
< 0.001). However, the OS, relapse, and TRM were not different between the two groups.
Conclusions
In summary, about two-thirds of the patients undergoing daily TBI experienced PT, which affected OS. Therefore, reducing the dose rate (less than 6 cGy/min) of TBI can decrease the risk of PT, without compromising the treatment efficacy.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Adult
/ Aged
/ Biomedical and Life Sciences
/ Child
/ Complications and side effects
/ Dose Fractionation, Radiation
/ Female
/ Graft vs Host Disease - prevention & control
/ Hematologic Neoplasms - mortality
/ Hematologic Neoplasms - radiotherapy
/ Hematopoietic stem cell transplantation
/ Hematopoietic Stem Cell Transplantation - mortality
/ Humans
/ Imaging
/ Infant
/ Male
/ Methods
/ Oncology
/ Transplantation Conditioning - adverse effects
/ Transplantation Conditioning - methods
/ Transplantation Conditioning - mortality
/ Whole-Body Irradiation - adverse effects
/ Whole-Body Irradiation - methods
