Journal Article

Different hypothermic and cerebral perfusion strategies in extended arch replacement for acute type a aortic dissection: a retrospective comparative study

Xu, Shang-Dong, Dong, Song-Bo, Liu, Yong-Min, Pan, Xu-Dong, Xiong, Jian-Xian, Zhang, Kai, Zheng, Jun, Sun, Li-Zhong

2020

Overview

Background The optimal hypothermic level in total arch replacement with stented elephant trunk implantation for acute type A aortic dissection (aTAAD) has not been established, and the superiority of unilateral or bilateral cerebral perfusion remains a controversial issue. Therefore, we evaluated the application of moderate hypothermic circulatory arrest (MHCA) with a core temperature of 29 °C and bilateral selective antegrade cerebral perfusion in aTAAD treated by total arch replacement with stented elephant trunk implantation. Methods From July 2019 to January 2020, 25 aTAAD patients underwent total arch replacement with stented elephant trunk implantation via MHCA (29 °C) and bilateral selective antegrade cerebral perfusion (modified group). Thirty-six patients treated by the same procedure with MHCA (25 °C) and unilateral selective antegrade cerebral perfusion during this period were selected as controls. Results There were no differences between the two groups of patients in terms of age, sex, incidence of hypertension, malperfusion, and pericardial effusion, although the incidence of cardiac tamponade was higher in the modified group (control 2.8%, modified 20%; P  = 0.038). The lowest mean circulatory arrest temperature was 24.6 ± 0.9 °C in the control group, and 29 ± 0.8 °C in the modified group ( P  <  0.001). In-hospital mortality was 4.9% (3/61) for the entire cohort (control 8.3%, modified 0; P  = 0.262). The incidence of permanent neurologic deficit was 4.9% (control 8.3%, modified 0; P  = 0.262). There were no significant differences in the occurrence of temporary neurological deficit, renal failure, and paraplegia between groups. The rate of major adverse events in the modified group was lower (30.6% vs. 4%, P  = 0.019). A shorter duration of ventilation and ICU stay was identified in the modified group, as well as a reduced volume of drainage within the first 48 h and red blood cell transfusion. Conclusions The early results of MHCA (29 °C) and bilateral selective antegrade cerebral perfusion applied in total arch replacement with stented elephant trunk implantation for aTAAD were acceptable, providing similar inferior cerebral and visceral protection compared with that of the conventional strategy. A higher core temperature may account for the shorter duration of ventilation and ICU stay, as well as a reduced volume of drainage and red blood cell transfusion.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acute type a aortic dissection / Adult / Analysis / Aneurysm, Dissecting - surgery / Aorta / Aorta, Thoracic - surgery / Aortic dissection / Arterial lines / Bilateral selective antegrade cerebral perfusion / Blood transfusion / Blood Vessel Prosthesis Implantation - adverse effects / Body Temperature / Cardiac function / Cardiac Surgery / Carotid arteries / Cerebrovascular Circulation / Coma / Comparative studies / Cooling / Coronary vessels / Dissection / Drainage measurement / Effusion / Elephants / Erythrocytes / Female / Heart Arrest, Induced - adverse effects / Heart Arrest, Induced - methods / Hospital Mortality / Humans / Hypertension / Hypothermia, Induced - adverse effects / Implantation / Intensive Care Units / Length of Stay / Male / Medical imaging / Medical prognosis / Medicine / Medicine & Public Health / Middle Aged / Moderate hypothermic circulatory arrest / Mortality / Nervous System Diseases - etiology / Normal distribution / Paralysis / Paraplegia / Paraplegics / Patients / Perfusion / Perfusion - adverse effects / Perfusion - methods / Renal failure / Research Article / Respiration, Artificial / Retrospective Studies / Risk Factors / Stents / Surgery / Tamponade / Thoracic Surgery / Time Factors / Total arch replacement / Veins & arteries / Ventilation