Asset Details
Do you wish to reserve the book?
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study
Do you wish to request the book?
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study
2019
Overview
Background
No study has been conducted to demonstrate the feasibility of an opioid-free anesthesia (OFA) protocol in cardiac surgery to improve patient care. The aim of the present study was to evaluate the effect of OFA on post-operative morphine consumption and the post-operative course.
Methods
After retrospectively registering to clinicaltrial.gov (NCT03816592), we performed a retrospective matched cohort study (1:1) on cardiac surgery patients with cardiopulmonary bypass between 2018 and 2019. Patients were divided into two groups: OFA (lidocaine, dexamethasone and ketamine) or opioid anaesthesia (OA) (sufentanil). The main outcome was the total postoperative morphine consumption in the 48 h after surgery. Secondary outcomes were rescue analgesic use, a major adverse event composite endpoint, and ICU and hospital length of stay (LOS).
Results
One hundred ten patients were matched (OFA:
n
= 55; OA: n = 55). On inclusion, demographic and surgical data for the OFA and OA groups were comparable. The total morphine consumption was higher in the OA group than in the OFA group (15 (6–34) vs 5 mg (2–18),
p
= 0.001). The pain score during the first 48 post-operative hours did not differ between the two groups. Creatinine values did not differ on the first post-operative day (80 (IQR: 66–115) vs 77 mmol/l (IQR: 69–95),
p
= 0.284). Incidence of the composite endpoint was lower in the OFA group (25 patients (43%) vs 38 patients (68%),
p
= 0.021). The time to extubation and the ICU stays were shorter in the OFA group (3 (1–5) vs 5 (3–6) hours, p = 0.001 and 2 (1–3) vs 3 (2–5) days,
p
= 0.037).
Conclusion
The use of OFA was associated with lower morphine consumption. OFA might be associated with shorter intubation time and ICU stays. Further randomized studies are needed to confirm these results.
Trial registration
This study was retrospectively registered to ct2 (identifier:
NCT03816592
) on January 25, 2019.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Analgesics - therapeutic use
/ Analgesics, Opioid - therapeutic use
/ Anesthetics, Local - therapeutic use
/ Antiemetics - therapeutic use
/ Antihypertensive Agents - therapeutic use
/ Control
/ Dexamethasone - therapeutic use
/ Drug Utilization - statistics & numerical data
/ Female
/ Humans
/ Length of Stay - statistics & numerical data
/ Male
/ Medicine
/ Methods
/ Morphine
/ Noninvasive Ventilation - statistics & numerical data
/ Opioid
/ Opioids
/ Pain, Postoperative - prevention & control
/ Perioperative medicine and outcome
/ Propofol
