Journal Article

Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis

Schneider, Kim Maren, Kummer, Peter, Wang, Wei, de Lepper, Marion, Luzak, Agnes, Jacob, Christian, Goelz, Rangmar, Reuschenbach, Miriam, Stephan, Anna-Janina, Greiner, Wolfgang, Hamprecht, Klaus, Buxmann, Horst, Wölle, Regine, Modrow, Susanne

2023

Overview

Background Congenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 years of life. Methods We conducted a retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database. Incremental healthcare costs during the first and second year of life were assessed by matching (1:60) infants with cCMV diagnoses ≤ 90 days after birth (cCMV 90 cohort) to infants without cCMV diagnosis (“representative” controls) and infants with cCMV diagnoses ≤ 21 days after birth plus specific symptoms (cCMV 21-S ) to infants without cCMV and any ICD-10-GM records (besides Z00-Z99) until 4 th preventive health check-up (“healthy” controls). Due to missing data, mean imputation was applied for aids and remedies costs. Results We identified 54 and 24 infants born 2014–2018 for the cCMV 90 and cCMV 21-S cohorts, respectively. During the first year, mean (median) healthcare costs were significantly higher in cCMV 90 cases vs. “representative” controls (€22,737 (€9759) vs. €3091 (€863), p < 0.001), with 87.2% inpatient costs. Healthcare costs for cCMV 21-S cases compared to “healthy” controls were €34,498 (€20,924) vs. €680 (€569), p < 0.001. Differences decreased for both comparisons in the second year but remained statistically significant. Conclusions cCMV comprises a considerable economic burden for the German healthcare system (€19,646 to €33,818 higher mean costs for infants with recorded cCMV diagnosis in the first year of life). Attempts should be made to reduce this burden.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Administrative data / Analysis / Babies / Birth weight / Congenital CMV infection / Congenital diseases / Costs / Cytomegalovirus / Cytomegalovirus infections / Data analysis / Diseases / Economic aspects / Germany / Health Administration / Health care expenditures / Health economic burden / Health Economics / Health Services Research / Hearing loss / Infants (Newborn) / Infections / Inpatient care / Medical care, Cost of / Medicine / Medicine & Public Health / Mortality / Newborn babies / Newborns / Pharmacoeconomics and Health Outcomes / Population / Postpartum period / Pregnancy / Public Health / Quality of Life Research / Womens health