Journal Article

Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation

Sedrak, Marize G, Mousa, Shaker A, Ahmed, Mona I, Aly, Aya A, Khalaf, Aya A, Abdelnaby, Sherouk M, Kamel, Reham M, Mohamad, Ebtesam A, Abdelzaher, Yasmine H

2021

Overview

Skin aging is a normal process that might be accelerated or delayed by altering the balance between antioxidants and free radicals due to increase in the exposure to reactive oxygen species (ROS) into skin cells via UV radiation. Antioxidants can neutralize the harmful effects of ROS, and secondary plant metabolites might help protect against UV radiation. In this study, punicalagin was extracted from pomegranate, and concentrations of total polyphenolics and flavonoids were determined, and antioxidant activities were measured. Punicalagin was loaded onto niosomes, and its morphology and release were studied. An in vitro study was performed on human fibroblast cell line HFB4 cells with aging induced by H O and UV radiation. Cell cycle arrest was studied, and different genes ( , and ) involved in the skin aging process were selected to measure punicalagin's effect. Punicalagin succeeded in reducing the growth arrest of HFB4 cells, activated production of the and genes, maintained collagen level, and lowered . Punicalagin increased human concentration in skin cells. Punicalagin is promising as a natural antioxidant to protect human skin from aging.

• Publisher: Dove Medical Press Limited,Taylor & Francis Ltd,Dove,Dove Medical Press
• Subject: Aging / Aging (artificial) / Aging (natural) / Analysis / Antioxidants / Antioxidants - pharmacology / Care and treatment / Cell cycle / Cell Proliferation - drug effects / Cells, Cultured / Collagen / Collagen (type I) / Dietary minerals / Ethylenediaminetetraacetic acid / Flavonoids / Free radicals / Free radicals (Chemistry) / Fruits / Genes / Human performance / Humans / Hydrogen peroxide / Hydrolyzable Tannins - administration & dosage / Hydrolyzable Tannins - isolation & purification / Hydrolyzable Tannins - pharmacology / Isoflavones / Liposomes - administration & dosage / Metabolites / Morphology / niosomes / Original Research / Oxidants / Oxidants - adverse effects / Oxidative stress / Oxidizing agents / Plant metabolites / Proteins / punicalagin / Reactive oxygen species / Seeds / Skin / skin aging / Skin Aging - drug effects / Skin Aging - radiation effects / Telomerase / Tissue inhibitor of metalloproteinase 3 / Ultraviolet radiation / Ultraviolet Rays - adverse effects / uv radiation