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CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
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CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
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CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
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Journal Article
CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
2023
Overview
CAR T cell-based therapies have revolutionized the treatment of hematological malignancies such as leukemia and lymphoma within the last years. In contrast to the success in hematological cancers, the treatment of solid tumors with CAR T cells is still a major challenge in the field and attempts to overcome these hurdles have not been successful yet. Radiation therapy is used for management of various malignancies for decades and its therapeutic role ranges from local therapy to a priming agent in cancer immunotherapy. Combinations of radiation with immune checkpoint inhibitors have already proven successful in clinical trials. Therefore, a combination of radiation therapy may have the potential to overcome the current limitations of CAR T cell therapy in solid tumor entities. So far, only limited research was conducted in the area of CAR T cells and radiation. In this review we will discuss the potential and risks of such a combination in the treatment of cancer patients.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Biomedical and Life Sciences
/ Cancer
/ Cells
/ Hematologic Neoplasms - etiology
/ Humans
/ Immune checkpoint inhibitors
/ Immunotherapy, Adoptive - adverse effects
/ Leukemia
/ Ligands
/ Lymphoma
/ Molecular understanding and clinical aspects of immunotherapy in the treatment of cancer
/ Mutation
/ Oncology
/ Review
/ T cells
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