Journal Article

Quality of life and overall well-being between healthy individuals and patients with varied clinical diagnoses

Bujang, Mohamad Adam, Tan, Clare Hui Hong, Yap, Eileen Pin Pin, Husin, Masliyana, Tiong, Xun Ting, Yee, Khoo Sing, Kim, Alex Ren Jye, Lai, Wei Hong, Hon, Yoon Khee, Jee, Yvonne Yih Huan, Ahmad, Nurul Fatma Diyana, Fong, Alan Yean Yip, Johari, Fazalena, Ratnasingam, Selvasingam

2025

Overview

Background Chronic diseases are known to detrimentally impact an individual’s quality of life (QOL) and well-being. Therefore, this study aims to evaluate the QOL and overall well-being among both healthy individuals and those with diverse primary diagnoses. Methods This is a cross-sectional study and data collection took place from May 2022 to May 2023. Information regarding healthy participants was gathered from healthcare workers without any comorbidities. Data for non-healthy participants were collected from individuals diagnosed with various conditions across four specialist clinics: nephrology, oncology, psychiatry, and cardiology. All participants completed the Significant Quality of Life Measures (SigQOLM), a comprehensive assessment tool consisting of 69 items that evaluate 18 domains of QOL and well-being. Results The study included a total of 452 participants, with 284 (62.8%) classified as healthy. Among the non-healthy participants, 41 (9.1%) had end-stage renal diseases (ESRD), 48 (10.6%) were diagnosed with cancer, 40 (8.8%) had depressive disorder, and the remaining had heart disease (8.6%). Statistical analysis revealed significant differences ( p  < 0.001) between healthy and non-healthy participants in both overall SigQOLM scores and across all 18 domains of SigQOLM. Conclusion Generally, healthy participants also experienced excellent QOL and well-being. However, disparities in both QOL and overall well-being were evident among patients with various diagnoses. These findings provide valuable insights for medical practitioners and policy makers by enabling them to tailor interventions to enhance the QOL and well-being of their patients.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Aged / Analysis of covariance / Biostatistics / Cancer / Cardiology / Cardiovascular disease / Cardiovascular diseases / Chronic Disease - psychology / Chronic diseases / Chronic illnesses / Chronic kidney failure / Chronically ill / Comorbidity / Complications and side effects / Cross-Sectional Studies / Data collection / Depression, Mental / End-stage renal disease / Environmental Health / Epidemiology / Ethics / Evaluation / Female / Health / Health aspects / Health Status / Healthy / Healthy Volunteers - psychology / Healthy Volunteers - statistics & numerical data / Heart / Heart diseases / Humans / Kidney diseases / Male / Medical diagnosis / Medical personnel / Medical research / Medicine / Medicine & Public Health / Medicine, Experimental / Mental depression / Middle Aged / Multivariate analysis / Neoplasms - psychology / Non-healthy / Patients / Psychiatry / Psychological aspects / Public Health / Quality of life / Quality of Life - psychology / SigQOLM / Statistical analysis / Surveys / Surveys and Questionnaires / Vaccine / Well being