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IL-6 as a keystone cytokine in health and disease
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Journal Article
IL-6 as a keystone cytokine in health and disease
2015
Overview
IL-6 has context-dependent pro- and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention. Hunter and Jones discuss the effect of IL-6 on innate and adaptive immunity, and consider how the immunobiology of IL-6 may inform clinical decisions.
Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not of the immune system and often displays hormone-like characteristics that affect homeostatic processes. IL-6 has context-dependent pro- and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention. However, the signaling cassette that controls the activity of IL-6 is complicated, and distinct intervention strategies can inhibit this pathway. Clinical experience with antagonists of IL-6 has raised new questions about how and when to block this cytokine to improve disease outcome and patient wellbeing. Here we discuss the effect of IL-6 on innate and adaptive immunity and the possible advantages of various antagonists of IL-6 and consider how the immunobiology of IL-6 may inform clinical decisions.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Antibodies, Blocking - pharmacology
/ B cells
/ Diseases
/ Drug Evaluation, Preclinical
/ Hormones
/ Humans
/ Inflammatory Bowel Diseases - immunology
/ Inflammatory Bowel Diseases - therapy
/ Interleukin-6 - antagonists & inhibitors
/ Receptors, Interleukin-6 - metabolism
/ Spondylitis, Ankylosing - immunology
