Asset Details
Do you wish to reserve the book?
Alternative splicing as a regulator of development and tissue identity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Alternative splicing as a regulator of development and tissue identity
Do you wish to request the book?
Alternative splicing as a regulator of development and tissue identity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Alternative splicing as a regulator of development and tissue identity
2017
Overview
Key Points
Alternative splicing explains how a single gene can generate more than one mRNA transcript, thus expanding the complexity of the proteome.
During normal development, a large number of alternative splicing changes occur, and it is now apparent that these transitions between alternatively spliced isoforms contribute to the acquisition of adult tissue functions and identity.
Individual splicing changes are coordinated during development, establishing splicing networks.
As a result of recent progress, we now better understand the mechanisms that coordinate alternative splicing networks and the roles of these networks in cell differentiation, organ development and tissue homeostasis.
Alternative splicing expands the complexity of the proteome by generating multiple transcript isoforms from a single gene. Numerous alternative splicing events occur during cell differentiation and tissue maturation, suggesting that alternative splicing supports proper development. Recent studies shed light on how alternative splicing and its coordination contribute to organ development and tissue homeostasis.
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
