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Taste buds: cells, signals and synapses
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Taste buds: cells, signals and synapses
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Taste buds: cells, signals and synapses
Taste buds: cells, signals and synapses
Journal Article

Taste buds: cells, signals and synapses

2017
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Overview
Key Points Taste buds are composed of two excitable cell types and a glia-like cell; each type of cell has distinct functions. Basic taste qualities are detected by G protein-coupled type 1 and type 2 taste receptors, by other receptors and ion channels, and possibly by transporters. ATP is an afferent taste transmitter and is secreted by taste bud cells through an unconventional, non-vesicular release mechanism. ATP, serotonin and GABA mediate cell–cell interactions in the taste bud that may shape transmission to sensory afferent fibres. Controversy remains regarding whether peripheral taste coding follows a labelled-line or combinatorial pattern. Taste preferences and appetites seem to have a genetic component that is being revealed by molecular and population studies. Mammals detect the nutrient content, palatability and potential toxicity of food through taste buds that are present mainly in the tongue. In this Review, Roper and Chaudhari discuss the taste bud cells, receptors and transmitters that are involved in taste detection, how these cells communicate with sensory afferent fibres, and peripheral taste coding. The past decade has witnessed a consolidation and refinement of the extraordinary progress made in taste research. This Review describes recent advances in our understanding of taste receptors, taste buds, and the connections between taste buds and sensory afferent fibres. The article discusses new findings regarding the cellular mechanisms for detecting tastes, new data on the transmitters involved in taste processing and new studies that address longstanding arguments about taste coding.