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The critical omission of CRRT dose in comparative studies of RRT modalities for sepsis-associated AKI
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The critical omission of CRRT dose in comparative studies of RRT modalities for sepsis-associated AKI
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Journal Article
The critical omission of CRRT dose in comparative studies of RRT modalities for sepsis-associated AKI
2025
Overview
[...]prior trials comparing IRRT and CRRT emphasized dose parity between modalities (i.e., ensuring equivalent total solute clearance when comparing outcomes) [7], a factor not addressed in this study. Without dose data, the study cannot disentangle whether outcomes reflect modality efficacy, dosing adequacy, or the balance between solute control and hemodynamic tolerance. [...]Uchino et al.’s observational study found no mortality difference between Japanese low-dose CRRT and historical international standards, but confounding factors such as patient selection and concurrent therapies cannot be ruled out [8].
Publisher
Springer Berlin Heidelberg,Springer Nature B.V,SpringerOpen
