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Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans
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Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans
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Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans
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Journal Article
Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans
2025
Overview
The Gram-positive organism
Filifactor alocis
is implicated in multiple oral diseases including periodontitis, and approximately 50% of known strains encode and produce a recently identified repeat-in-toxin (RTX) protein, FtxA, partly homologous to the
Aggregatibacter actinomycetemcomitans
leukotoxin. By assessing a longitudinal Ghanaian study population of adolescents, we recently identified a possible correlation between
F. alocis
levels,
ftxA
gene carriage, and progression of clinical attachment loss (CAL). To extend knowledge on the possible significance of
F. alocis
and its FtxA in periodontal disease, we have in the present work analyzed saliva samples in an independent cohort of periodontitis (n=156), collected at two private periodontal specialist practices in Perth, Western Australia. The present results corroborate that high loads of
F. alocis
and the presence of its
ftxA
gene together are associated with parameters of periodontal tissue destruction and severity. Moreover, among the individuals carrying
A. actinomycetemcomitans
, a majority also exhibited an
ftxA
-positive
F. alocis
, supporting the notion of the synergistic behavior of these two species. This emphasizes that
F. alocis
and its
ftxA
are involved in the pathogenesis of periodontitis and may have ecological roles, with diagnostic and prognostic implications for the disease.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Adult
/ Aggregatibacter actinomycetemcomitans
/ Aggregatibacter actinomycetemcomitans - genetics
/ Aggregatibacter actinomycetemcomitans - isolation & purification
/ Bacterial Proteins - genetics
/ Cellular and Infection Microbiology
/ clinical attachment loss (CAL)
/ Female
/ ftxA
/ Humans
/ Male
/ Periodontitis - epidemiology
/ Periodontitis - microbiology
/ Saliva
/ Teeth
/ Toxins
