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Very pronounced bowel sparing during radiation therapy for anal carcinoma using a natural spacer (Myoma) – a case report
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Very pronounced bowel sparing during radiation therapy for anal carcinoma using a natural spacer (Myoma) – a case report
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Journal Article
Very pronounced bowel sparing during radiation therapy for anal carcinoma using a natural spacer (Myoma) – a case report
2024
Overview
Background
Using dose-painted intensity-modulated radiation therapy, specific dose volume constraints or implantation of tissue expanders prior to radiotherapy are validated options for reducing radiation dose on the bowel and therefore minimizing acute gastrointestinal toxicity during chemoradiation for anorectal malignancies. We describe the rare case of a female patient with a locally advanced anal carcinoma where a large myomatous uterus served as a natural spacer to protect the bowel during radiation therapy.
Case presentation
Initially the patient presented with anal pain, proctoscopy followed by an excisional biopsy confirmed the diagnosis of a squamous cell carcinoma of the anus. Imaging examination showed a locally advanced tumor and in addition a large uterus with typical leiomyomas up to 11.5 cm in diameter. The patient underwent chemoradiation; because of the large leiomyomas there was almost no dose burden for the small intestine and therefore practically no gastrointestinal toxicity.
Conclusion
As we know, this report describes the situation that a large myomatous uterus served as a natural spacer during radiation therapy in a way that is unique to date.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Anus Neoplasms - radiotherapy
/ Biomedical and Life Sciences
/ Cancer
/ Carcinoma, Squamous Cell - pathology
/ Carcinoma, Squamous Cell - radiotherapy
/ Female
/ Humans
/ Imaging
/ Myoma
/ Oncology
/ Organ Sparing Treatments - methods
/ Organs at Risk - radiation effects
/ Radiation Injuries - etiology
/ Radiotherapy, Intensity-Modulated - adverse effects
/ Radiotherapy, Intensity-Modulated - methods
/ Toxicity
