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Transportable hyperpolarized metabolites
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Journal Article
Transportable hyperpolarized metabolites
2017
Overview
Nuclear spin hyperpolarization of
13
C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled
in vivo
metabolic imaging by MRI. However, because of the short lifetime of the hyperpolarized magnetization (typically <1 min), the polarization process must be carried out close to the point of use. Here we introduce a concept that markedly extends hyperpolarization lifetimes and enables the transportation of hyperpolarized metabolites. The hyperpolarized sample can thus be removed from the polarizer and stored or transported for use at remote MRI or NMR sites. We show that hyperpolarization in alanine and glycine survives 16 h storage and transport, maintaining overall polarization enhancements of up to three orders of magnitude.
MRI imaging can be significantly enhanced by injecting highly magnetized chemical agents, but the short magnetization lifetime requires processing at the point of use. Here, the authors demonstrate a method that could extend the lifetime from seconds to hours, enabling remote preparation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
