Journal Article

Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Zheng, Zhen, Zou, Xiaobing, Zheng, Peng

2021

Overview

The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41–1.53; p  < 0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD.

• Publisher: Springer US,Springer,Springer Nature B.V
• Subject: Analysis / Anatomy / Autism / Autism Spectrum Disorders / Behavioral Science and Psychology / Biological markers / Blood / Brain / Calcium / Calcium-binding protein / Center and periphery / Central nervous system / Child and School Psychology / Chinese / Control Groups / Database Management Systems / Genetic aspects / Genetics / Individualized Instruction / Influence of Technology / Interpersonal Relationship / Mental Disorders / Meta Analysis / Metabolism / Nervous system / Neurological Impairments / Neurosciences / Original Paper / Pediatrics / Peripheral blood / Peripheral circulation / Pervasive Developmental Disorders / Psychology / Public Health / S100b protein / Sample Size / Schizophrenia / Statistical Analysis / Systematic review