Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals

by Hillary, Robert F. , Nevado‐Holgado, Alejo J. , Shi, Liu , Buckley, Noel J. , Waiter, Gordon , Whalley, Heather C. , Stolicyn, Aleks , Waymont, Jennifer , Steele, Douglas , Campbell, Archie , Backhouse, Ellen , Buchanan, Colin R. , Cox, Simon R. , Harris, Mathew A. , Mcintosh, Andrew , Wardlaw, Joanna M. , Lovestone, Simon , Marioni, Riccardo E. , Hayward, Caroline

in Alzheimer's disease / Atrophy / Biomarkers / Blood‐based Biomarkers / Dementia / Gender differences / Magnetic resonance imaging / mediation / Neurodegeneration / Pathogenesis / Pathology / Plasma / plasma proteomics / Proteins / sex‐related difference / Software / vascular damage

2021

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals

2021

Confirm

Do you wish to request the book?

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals

2021

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals

Hillary, Robert F.,

Nevado‐Holgado, Alejo J.,

Shi, Liu,

Buckley, Noel J.,

Waiter, Gordon,

Whalley, Heather C.,

Stolicyn, Aleks,

Waymont, Jennifer,

Steele, Douglas,

Campbell, Archie,

Backhouse, Ellen,

Buchanan, Colin R.,

Cox, Simon R.,

Harris, Mathew A.,

Mcintosh, Andrew,

Wardlaw, Joanna M.,

Lovestone, Simon,

Marioni, Riccardo E.,

Hayward, Caroline

2021

Overview

Introduction This study aims to first discover plasma proteomic biomarkers relating to neurodegeneration (N) and vascular (V) damage in cognitively normal individuals and second to discover proteins mediating sex‐related difference in N and V pathology. Methods Five thousand and thirty‐two plasma proteins were measured in 1061 cognitively normal individuals (628 females and 433 males), nearly 90% of whom had magnetic resonance imaging measures of hippocampal volume (as N) and white matter hyperintensities (as V). Results Differential protein expression analysis and co‐expression network analysis revealed different proteins and modules associated with N and V, respectively. Furthermore, causal mediation analysis revealed four proteins mediated sex‐related difference in N and one protein mediated such difference in V damage. Discussion Once validated, the identified proteins could help to select cognitively normal individuals with N and V pathology for Alzheimer's disease clinical trials and provide targets for further mechanistic studies on brain sex differences, leading to sex‐specific therapeutic strategies.

Share this book

Add to My Shelf

Publisher

John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley

Subject

Alzheimer's disease

/ Atrophy

/ Biomarkers

/ Blood‐based Biomarkers

/ Dementia

/ Gender differences

/ Magnetic resonance imaging