Journal Article

Molecular alterations in prostate cancer and association with MRI features

Barbieri, C E, MacDonald, T Y, Fontugne, J, Robinson, B D, Mosquera, J M, Rubin, M A, Lee, D, Gumpeni, N, Park, K, Sboner, A

2017

Overview

Background: Multiparametric magnetic resonance imaging (mpMRI) has been increasingly used for prostate cancer (PCa). Recent studies identified distinct molecular subclasses of PCa with recurrent genomic alterations. However, the associations between molecular alterations in PCa and characteristics on mpMRI are unknown. Therefore, the objective of this study was to investigate recurrent molecular alterations in PCa and their associations with mpMRI features. Methods: Sixty-two PCa nodules >0.5 cm had a preoperative mpMRI. Nodules were evaluated for ERG rearrangement, PTEN deletion, SPINK1 overexpression, SPOP mutation and CHD1 deletion. Each PCa focus was matched to the corresponding location on mpMRI. Lesions were scored by single observer according to the PI-RADSv2 scale. Results: Of the 62 nodules, 22 (35.5%) were ERG positive, 6 (9.7%) had SPINK1 overexpression, 6 (9.7%) had SPOP mutations, 4 (6.5%) had CHD1 deletions and 1 (1.6%) had PTEN deletion. All of the nodules with CHD1 deletions were not visible on mpMRI ( P =0.037). All of the nodules with SPINK1 overexpression were visible on mpMRI, although the association was not statistically significant ( P =0.06). There were no significant associations between any molecular alteration with the severity of the PI-RADS scores (all P >0.05). Conclusions: This investigation represents the first description of an association between recurrent molecular alterations and the characterization of PCa nodules on mpMRI. This study can be considered hypothesis-generating for future studies to rigorously evaluate the association of specific PCa molecular subclasses with imaging features and potentially define specific subsets of PCa for which the utility of MRI is higher or lower.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 59/57 / 631/67/589/466 / 631/67/68 / 692/308/53 / Aged / Biomedical and Life Sciences / Biomedicine / Cancer Research / Care and treatment / Diagnosis / DNA Helicases - genetics / DNA-Binding Proteins - genetics / Gene deletion / Gene Expression Regulation, Neoplastic - genetics / Genetic aspects / Humans / Lesions / Magnetic Resonance Imaging / Male / Medical imaging / Middle Aged / Molecular diagnostic techniques / Mutation / NMR / Nodules / Nuclear magnetic resonance / Nuclear Proteins - genetics / original-article / Prostate - diagnostic imaging / Prostate - pathology / Prostate - surgery / Prostate cancer / Prostatic Neoplasms - diagnostic imaging / Prostatic Neoplasms - genetics / Prostatic Neoplasms - pathology / Prostatic Neoplasms - surgery / PTEN Phosphohydrolase - genetics / PTEN protein / Repressor Proteins - genetics / Statistical analysis / Transcriptional Regulator ERG - genetics / Trypsin Inhibitor, Kazal Pancreatic - genetics