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Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

by Yokoyama, Wayne M , Wang, Qiuling , Zaitsev, Konstantin , Bern, Michael , Patel, Swapneel , Andhey, Prabhakar , Collins, Patrick , Oltz, Eugene , Porter, Sophia , Colonna, Marco , Hershey, Maxwell , Artyomov, Maxim , Park, Eugene , Sibley, L David , Plougastel-Douglas, Beatrice , Murphy, Kenneth M

in Animals / B cells / Cell Transdifferentiation / Cytokines / Disease Models, Animal / Epigenetic inheritance / ILC / Immunology and Inflammation / Infection / Killer cells / Killer Cells, Natural - immunology / Mice / NK cells / Physiological aspects / T-Box Domain Proteins - metabolism / toxoplasma / Toxoplasma - immunology / Toxoplasmosis / Toxoplasmosis - immunology / Tumors

2019

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Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

2019

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Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

2019

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Journal Article

Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

Yokoyama, Wayne M,

Wang, Qiuling,

Zaitsev, Konstantin,

Bern, Michael,

Patel, Swapneel,

Andhey, Prabhakar,

Collins, Patrick,

Oltz, Eugene,

Porter, Sophia,

Colonna, Marco,

Hershey, Maxwell,

Artyomov, Maxim,

Park, Eugene,

Sibley, L David,

Plougastel-Douglas, Beatrice,

Murphy, Kenneth M

2019

Overview

Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state. However, tumors may induce NK cell conversion into ILC1-like cells that are limited to the tumor microenvironment and whether this conversion occurs beyond this environment remains unknown. Here, we describe Toxoplasma gondii infection converts NK cells into ILC1-like cells that are distinct from both steady-state NK cells and ILC1s in uninfected mice. These cells were Eomes-dependent, indicating that NK cells can give rise to Eomes– Tbet-dependent ILC1-like cells that circulate widely and persist independent of ongoing infection. Moreover, these changes appear permanent, as supported by epigenetic analyses. Thus, these studies markedly expand current concepts of NK cells, ILCs, and their potential conversion.

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Publisher

eLife Science Publications, Ltd,eLife Sciences Publications, Ltd,eLife Sciences Publications Ltd

Subject

Animals

/ B cells

/ Cell Transdifferentiation

/ Cytokines

/ Disease Models, Animal

/ Epigenetic inheritance

/ ILC