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Smell and taste dysfunction in patients with COVID-19
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Smell and taste dysfunction in patients with COVID-19
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Smell and taste dysfunction in patients with COVID-19
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Journal Article
Smell and taste dysfunction in patients with COVID-19
2020
Overview
The plural of an anecdote is not evidence, yet anecdotal international reports are accumulating from ear, nose, and throat (ENT) surgeons and other health-care workers on the front lines that anosmia, with or without dysgeusia, are symptoms frequently associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To further complicate matters, immediate self-recognition of olfactory dysfunction is typically only present in the most severe cases, or it is only self-identified after a prolonged latency period.1,2 A scarcity of acute-phase advanced neuroimaging studies, difficulties in obtaining histopathological tissue specimens, and an absence of viral cultures of infected olfactory neuroepithelium compound the difficulties in studying this phenomenon. [...]in the context of normal trans-nasal airflow of odorant molecules (ie, no oedema in the nasal vault or olfactory cleft), and in the absence of intranasal disease (eg, infectious rhinosinusitis, allergic or vasomotor rhinitis, or polyposis), until now patients with sensorineural viral anosmia have been seldom seen in general otolaryngology practice—on the order of approximately one to two new-onset patients each year. [...]up until the coronavirus disease 2019 (COVID-19) pandemic, the low prevalence of sensorineural viral anosmia in society as a whole has made clinical research challenging.
Publisher
Elsevier Ltd,Elsevier Limited,New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001
Subject
/ Anosmia
/ Betacoronavirus - isolation & purification
/ Coronavirus Infections - complications
/ Coronavirus Infections - diagnosis
/ Coronavirus Infections - physiopathology
/ Coronavirus Infections - virology
/ COVID-19
/ Edema
/ Humans
/ Latency
/ Microbiology and Parasitology
/ Olfaction Disorders - complications
/ Olfaction Disorders - physiopathology
/ Pneumonia, Viral - complications
/ Pneumonia, Viral - diagnosis
/ Pneumonia, Viral - physiopathology
/ Rhinitis
/ Severe acute respiratory syndrome coronavirus 2
/ Smell
/ Taste
/ Virology
