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Poly( -caprolactone)-carbon nanotube composite scaffolds for enhanced cardiac differentiation of human mesenchymal stem cells
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Poly( -caprolactone)-carbon nanotube composite scaffolds for enhanced cardiac differentiation of human mesenchymal stem cells
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Journal Article
Poly( -caprolactone)-carbon nanotube composite scaffolds for enhanced cardiac differentiation of human mesenchymal stem cells
2013
Overview
To evaluate the efficacy of electrically conductive, biocompatible composite scaffolds in modulating the cardiomyogenic differentiation of human mesenchymal stem cells (hMSCs).
Electrospun scaffolds of poly( -caprolactone) with or without carbon nanotubes were developed to promote the
cardiac differentiation of hMSCs.
Results indicate that hMSC differentiation can be enhanced by either culturing in electrically conductive, carbon nanotube-containing composite scaffolds without electrical stimulation in the presence of 5-azacytidine, or extrinsic electrical stimulation in nonconductive poly( -caprolactone) scaffolds without carbon nanotube and azacytidine.
This study suggests a first step towards improving hMSC cardiomyogenic differentiation for local delivery into the infarcted myocardium.
Original submitted 23 July 2012; Revised submitted 31 October 2012; Published online 27 March 2013
Publisher
Future Medicine Ltd,Future Medicine
Subject
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
/ Applied cell therapy and gene therapy
/ Biological and medical sciences
/ Cell Differentiation - physiology
/ Cross-disciplinary physics: materials science; rheology
/ Exact sciences and technology
/ Humans
/ Mesenchymal Stromal Cells - cytology
/ Nanoscale materials and structures: fabrication and characterization
/ Nanotubes, Carbon - chemistry
/ Physics
/ Tissue Engineering - methods
/ Tissue Scaffolds - chemistry
/ Transfusions. Complications. Transfusion reactions. Cell and gene therapy
