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RNA binding proteins in spermatogenesis： an in depth focus on the Musashi family
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Journal Article
RNA binding proteins in spermatogenesis： an in depth focus on the Musashi family
2015
Overview
Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the complex process of mammalian spermatogenesis, male germ cells experience extended periods of the inactive transcription despite heavy translational requirements for continued growth and differentiation. Hence, spermatogenesis is highly reliant on mechanisms of posttranscriptional regulation of gene expression, facilitated by RNA binding proteins （RBPs）, which remain abundantly expressed throughout this process. One such group of proteins is the Musashi family, previously identified as critical regulators of testis germ cell development and meiosis in Drosophila, and also shown to be vital to sperm development and reproductive potential in the mouse. This review describes the role and function of RBPs our recent knowledge of the Musashi proteins in spermatogenesis. within the scope of male germ cell development, focusing on The functional mechanisms utilized by RBPs within the cell are outlined in depth, and the significance of sub-cellular localization and stage-specific expression in relation to the mode and impact of posttranscriptional regulation is also highlighted. We emphasize the historical role of the Musashi family of RBPs in stem cell function and cell fate determination, as originally characterized in Drosophila and Xenopus, and conclude with our current understanding of the differential roles and functions of the mammalian Musashi proteins, Musashi-1 and Musashi-2, with a primary focus on our findings in spermatogenesis. This review highlights both the essential contribution of RBPs to posttranscriptional regulation and the importance of the Musashi family as master regulators of male gamete development.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
Subject
/ Gene Expression Regulation, Developmental
/ Humans
/ Male
/ Mice
/ Musashi
/ Nerve Tissue Proteins - biosynthesis
/ Nerve Tissue Proteins - genetics
/ Proteins
/ RNA-Binding Proteins - biosynthesis
/ RNA-Binding Proteins - genetics
/ RNA结合蛋白
/ Rodents
/ Roles
/ splicing
/ Studies
/ testis
/ 家族
/ 焦点
/ 生殖细胞发育
/ 精子发生过程
/ 调控机制
/ 转录后调控
/ 雄配子体发育
