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E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
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E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
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E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
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Journal Article
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
2021
Overview
In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here, we demonstrate that the transcription factor E2F6, a member of the polycomb repressive complex 1.6 (PRC1.6), is critical to target and initiate epigenetic silencing at germline genes in early embryogenesis. Genome-wide, E2F6 binds preferentially to CpG islands in embryonic cells. E2F6 cooperates with MGA to silence a subgroup of germline genes in mouse embryonic stem cells and in embryos, a function that critically depends on the E2F6 marked box domain. Inactivation of
E2f6
leads to a failure to deposit CpG island DNA methylation at these genes during implantation. Furthermore, E2F6 is required to initiate epigenetic silencing in early embryonic cells but becomes dispensable for the maintenance in differentiated cells. Our findings elucidate the mechanisms of epigenetic targeting of germline genes and provide a paradigm for how transient repression signals by DNA-binding factors in early embryonic cells are translated into long-term epigenetic silencing during mouse development.
DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/15
/ 38/39
/ 38/77
/ 38/91
/ 45/22
/ 64/60
/ Biochemistry, Molecular Biology
/ DNA
/ Embryology and Organogenesis
/ Embryos
/ Genes
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Science
