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Long‐Term Recovery After Endothelial Colony‐Forming Cells or Human Umbilical Cord Blood Cells Administration in a Rat Model of Neonatal Hypoxic‐Ischemic Encephalopathy
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Long‐Term Recovery After Endothelial Colony‐Forming Cells or Human Umbilical Cord Blood Cells Administration in a Rat Model of Neonatal Hypoxic‐Ischemic Encephalopathy
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Long‐Term Recovery After Endothelial Colony‐Forming Cells or Human Umbilical Cord Blood Cells Administration in a Rat Model of Neonatal Hypoxic‐Ischemic Encephalopathy
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Journal Article
Long‐Term Recovery After Endothelial Colony‐Forming Cells or Human Umbilical Cord Blood Cells Administration in a Rat Model of Neonatal Hypoxic‐Ischemic Encephalopathy
2017
Overview
Neonatal hypoxic‐ischemic encephalopathy (NHIE) is a dramatic perinatal complication, associated with poor neurological prognosis despite neuroprotection by therapeutic hypothermia, in the absence of an available curative therapy. We evaluated and compared ready‐to‐use human umbilical cord blood cells (HUCBC) and bankable but allogeneic endothelial progenitors (ECFC) as cell therapy candidate for NHIE. We compared benefits of HUCBC and ECFC transplantation 48 hours after injury in male rat NHIE model, based on the Rice‐Vannucci approach. Based on behavioral tests, immune‐histological assessment and metabolic imaging of brain perfusion using single photon emission computed tomography (SPECT), HUCBC, or ECFC administration provided equally early and sustained functional benefits, up to 8 weeks after injury. These results were associated with total normalization of injured hemisphere cerebral blood flow assessed by SPECT/CT imaging. In conclusion, even if ECFC represent an efficient candidate, HUCBC autologous criteria and easier availability make them the ideal candidate for hypoxic‐ischemic cell therapy. Stem Cells Translational Medicine 2017;6:1987–1996 Neonatal hypoxic ischemic encephalopathy is a dramatic perinatal complication and to date no curative therapy available has been validated. Based on behavioral tests, immune‐histological assessment and metabolic imaging of brain perfusion using single photon emission computed tomography, we report in this work that transplantation of both human umbilical cord blood cells and endothelial progenitors provided equally early and sustained functional benefits, up to adulthood.
Publisher
Oxford University Press,Wiley,John Wiley and Sons Inc
Subject
/ Animals
/ Blood
/ Cord / Cord Blood Stem Cells (WJ‐MSCs)
/ Endothelial colony‐forming cells
/ Endothelial Progenitor Cells
/ Endothelial Progenitor Cells - cytology
/ Human umbilical cord blood cells
/ Humans
/ Hypoxia
/ Hypoxia-Ischemia, Brain - therapy
/ Ischemia
/ Ischemia / Reperfusion Injury
/ Male
/ Mesenchymal Stem Cell Transplantation - methods
/ Neonatal hypoxic ischemic encephalopathy
/ Neonates
/ Rats
/ Single photon emission computed tomography
/ Studies
