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Pre-Target Axon Sorting Establishes the Neural Map Topography
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Journal Article
Pre-Target Axon Sorting Establishes the Neural Map Topography
2009
Overview
Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of the map is determined by graded positional cues that are expressed by the target. Here, we analyzed the pre-target axon sorting for olfactory map formation in mice. In olfactory sensory neurons, an axon guidance receptor, Neuropilin-1, and its repulsive ligand, Semaphorin-3A, are expressed in a complementary manner. We found that expression levels of Neuropilin-1 determined both pre-target sorting and projection sites of axons. Olfactory sensory neuron-specific knockout of Semaphorin-3A perturbed axon sorting and altered the olfactory map topography. Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Axons
/ Biological and medical sciences
/ Brain
/ Cues
/ Fundamental and applied biological sciences. Psychology
/ Ligands
/ Mice
/ Neurons
/ Nose
/ Olfactory Mucosa - physiology
/ Olfactory Pathways - cytology
/ Olfactory Pathways - physiology
/ Olfactory Receptor Neurons - cytology
/ Olfactory Receptor Neurons - physiology
/ Olfactory system and olfaction. Gustatory system and gustation
