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Postural control impairments following neurotoxic chemotherapy in women with cancer: a prospective observational study
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Postural control impairments following neurotoxic chemotherapy in women with cancer: a prospective observational study
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Postural control impairments following neurotoxic chemotherapy in women with cancer: a prospective observational study
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Journal Article
Postural control impairments following neurotoxic chemotherapy in women with cancer: a prospective observational study
2025
Overview
Purpose
This study aimed to compare changes in postural control in different testing conditions involving sensory disturbances, quality of life and neurotoxicity concerns in women with cancer before and after chemotherapy with taxanes. The second aim was to compare postural control between chemotherapy-induced peripheral neuropathy (CIPN) severity subgroups.
Method
The 33 participants with breast cancer (age 48.15 ± 9.88 years) were tested during the month preceding (baseline) and the month after the end of chemotherapy. Postural control was assessed on a force platform (100 Hz) in different conditions: eyes open/closed, rigid/foam surface, with/without tendon vibration, dual task, and limits of stability. CIPN severity and neurotoxicity concerns were also evaluated. Paired t-tests or Wilcoxon sign rank tests were used, and a Benjamini-Hochberg correction was applied.
Results
After chemotherapy, greater postural adjustments were required to maintain balance in the reference condition (
p
≤ 0.02), and in conditions with visual (
p
≤ 0.02), foam (
p
≤ 0.04), and dual task disturbances (
p
≤ 0.01), but not in the vibration and limits of stability conditions. No difference was found between the CIPN subgroups. The neurotoxicity score worsened after chemotherapy (-8.61 ± 7.53,
p
≤ 0.01).
Conclusions
Postural control was impaired after chemotherapy, particularly in conditions with visual disturbances and dual task. Anteroposterior center of pressure displacements with mediolateral ground reaction forces were particularly increased.
Clinical implications
Systematic assessment of postural control with eyes closed in women with breast cancer would help to identify chemotherapy-induced postural control disorders and determine treatment needs.
Trial registration
Clinical Trial Registration number NCT04692168. Registration date: 28.12.2020
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Antineoplastic Agents - adverse effects
/ Antineoplastic Agents - therapeutic use
/ Breast Neoplasms - drug therapy
/ Cancer
/ Complications and side effects
/ Feedback
/ Female
/ Humans
/ Medicine
/ Neurotoxicity Syndromes - etiology
/ Neurotoxicity Syndromes - physiopathology
/ Peripheral Nervous System Diseases - chemically induced
/ Peripheral Nervous System Diseases - physiopathology
/ Postural Balance - drug effects
/ Postural Balance - physiology
/ Posture
