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Co-culture of oligodendrocytes and neurons can be used to assess drugs for axon regeneration in the central nervous system
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Co-culture of oligodendrocytes and neurons can be used to assess drugs for axon regeneration in the central nervous system
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Journal Article
Co-culture of oligodendrocytes and neurons can be used to assess drugs for axon regeneration in the central nervous system
2015
Overview
We present a novel in vitro model in which to investigate the efficacy of experimental drugs for the promotion of axon regeneration in the central nervous system. We co-cultured rat hippocampal neurons and cerebral cortical oligodendrocytes, and tested the co-culture system using a Nogo-66 receptor antagonist peptide（NEP1–40）, which promotes axonal growth. Primary cultured oligodendrocytes suppressed axonal growth in the rat hippocampus, but NEP1–40 stimulated axonal growth in the co-culture system. Our results confirm the validity of the neuron-oligodendrocyte co-culture system as an assay for the evaluation of drugs for axon regeneration in the central nervous system.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Neurological Hospital of Affiliated Hospital of Logistics University of Chinese People's Armed Police Force,Tianjin,China,Tianjin University of Traditional Chinese Medicine,Tianjin,China%Neurological Hospital of Affiliated Hospital of Logistics University of Chinese People's Armed Police Force,Tianjin,China%Logistics University of Chinese People's Armed Police Forces,Tianjin,China%Neurological Hospital of Affiliated Hospital of Logistics University of Chinese People's Armed Police Force,Tianjin,China,Liaoning Medical University,Jinzhou,Liaoning Province,China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
