Journal Article

Large animal models of human cauda equina injury and repair： evaluation of a novel goat model

Wen-tao Chen Pei-xun Zhang FengXue Xiao-feng Yin Cao-yuan Qi Jun Ma Bo Chen You-lai Yu Jiu-xu Deug Bao-guo Jiang

2015

Overview

Previous animal studies of cauda equina injury have primarily used rat models, which display significant differences from humans. Furthermore, most studies have focused on electrophysio- logical examination. To better mimic the outcome after surgical repair of cauda equina injury, a novel animal model was established in the goat. Electrophysiological, histological and magnetic resonance imaging methods were used to evaluate the morphological and functional outcome after cauda equina injury and end-to-end suture. Our results demonstrate successful establish- ment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgical repair of cauda equina injury.

• Publisher: Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Department of Trauma and 0rthopedics, Peking University People’s Hospital, Beijing, China%Department of Radiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
• Subject: Animal research models / Animals / Anisotropy / Care and treatment / Cauda equina / Caudal regression syndrome / Diagnosis / Electrodes / Electromyography / Histology / Injuries / nerve regeneration; spinal cord injury; goat; animal model; radiography; magnetic resonance imaging; diffusion tensor imaging; fiber bundle; diagnosis; injury; physiology; neuroimaging; NSFC grants; neural regeneration / Physiological aspects / Risk factors / Special Issue / Spinal cord / Surgery / Vertebrae / 人类 / 修复 / 动物模型 / 大鼠模型 / 山羊 / 磁共振成像 / 神经损伤 / 评价