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Primary-Effusion Lymphoma and Kaposi's Sarcoma in a Cardiac-Transplant Recipient
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Primary-Effusion Lymphoma and Kaposi's Sarcoma in a Cardiac-Transplant Recipient
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Journal Article
Primary-Effusion Lymphoma and Kaposi's Sarcoma in a Cardiac-Transplant Recipient
1998
Overview
Human herpesvirus 8 (HHV-8) is a recently discovered virus that appears to have a pathogenic role in Kaposi's sarcoma, multicentric Castleman's disease, and primary-effusion lymphoma, a distinctive lymphoma that arises within body-cavity effusions.
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HHV-8 was originally detected in lesions of Kaposi's sarcoma in patients infected with the human immunodeficiency virus (HIV) but was subsequently found in forms of the tumor that occur in HIV-negative patients.
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Similarly, HHV-8–associated multicentric Castleman's disease occurs predominantly in patients with the acquired immunodeficiency syndrome (AIDS) but also in HIV-negative patients.
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These findings suggest a direct causal role of HHV-8 in the . . .
Publisher
Massachusetts Medical Society
Subject
Biological and medical sciences
/ Cancer
/ Heart
/ Hematologic and hematopoietic diseases
/ Herpesviridae Infections - virology
/ Herpesvirus 8, Human - isolation & purification
/ Humans
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Male
/ Pleural Effusion, Malignant - pathology
/ Pleural Effusion, Malignant - virology
