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New Approach For Simvastatin As An Antibacterial: Synergistic Effect With Bio-Synthesized Silver Nanoparticles Against Multidrug-Resistant Bacteria
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Journal Article
New Approach For Simvastatin As An Antibacterial: Synergistic Effect With Bio-Synthesized Silver Nanoparticles Against Multidrug-Resistant Bacteria
2019
Overview
Multidrug-resistant bacteria such as extended-spectrum beta-lactamase (ESBL), Enterobacteriaceae, and methicillin-resistant
(MRSA) pose a challenge to the human health care system. MRSA is among the major causes of hospital-acquired and community infections.
Therefore, in the present study, we evaluated the antibacterial activity of silver nanoparticles synthesized by
(AgNP
) in combination with simvastatin against reference and multidrug-resistant bacterial strains.
Simvastatin showed a minimal inhibitory concentration (MIC) ranging from 0.062 to 0.25 mg mL
against MRSA. AgNP
with a size of 77.68± 33.95 nm and zeta potential -34.6 ± 12.7 mV showed an MIC of 0.212 mg mL
against
including MRSA strains. The checkerboard assay and time-kill curves exhibited a synergistic effect of the simvastatin-AgNP
combination on antibacterial activity against MRSA strains. The combination of simvastatin and AgNP
demonstrated antibacterial activity against
producing ESBL. Scanning electron microscopy showed the formation of cell surface protrusions after treatment with AgNP
and the formation of a large amorphous mass after treatment with simvastatin, both in MRSA.
Our results indicate that the combination of AgNP
and simvastatin could be a great future alternative in the control of bacterial infections, where, when combined with simvastatin, smaller doses of AgNP
are required, with the same antibacterial activity.
Publisher
Dove Medical Press Limited,Dove Press,Dove,Dove Medical Press
Subject
Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Drug resistance in microorganisms
/ Drug Resistance, Multiple, Bacterial - drug effects
/ Escherichia coli - drug effects
/ Humans
/ Metal Nanoparticles - chemistry
/ Metal Nanoparticles - ultrastructure
/ Methicillin-Resistant Staphylococcus aureus - drug effects
/ Methicillin-Resistant Staphylococcus aureus - ultrastructure
/ multidrug-resistant bacterial
/ Silver
/ Staphylococcus aureus infections
/ Statins
