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Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: A randomized controlled pilot study
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Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: A randomized controlled pilot study
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Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: A randomized controlled pilot study
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Journal Article
Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: A randomized controlled pilot study
2014
Overview
Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence this process. The aim of this study was to investigate the effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on telomeric shortening in elderly individuals with mild cognitive impairment (MCI).
Thirty-three adults ages > 65 y with MCI were randomized to receive a supplement rich in the long-chain ω-3 PUFAs eicosapentaenoic acid (EPA; 1.67 g EPA + 0.16 g docosahexaenoic acid DHA/d; n = 12) or DHA (1.55 g DHA + 0.40 g EPA/d; n = 12), versus ω-6 PUFA linoleic acid (LA; 2.2 g/d; n = 9) for 6 mo.
The intervention did not show an increase in telomere length with treatment and there was a trend toward telomere shortening during the intervention period. Linear mixed modeling produced a robust model although statistically underpowered. Telomere shortening was greatest in the LA group (d = 0.21) than in the DHA (d = 0.12) and EPA groups (d = 0.06). Increased erythrocyte DHA levels were associated with reduced telomere shortening (r = −0.67; P = 0.02) in the DHA group.
Telomeric shortening may be attenuated by ω-3 PUFA supplementation, requiring further investigation in larger samples.
Publisher
Elsevier Inc,Elsevier
Subject
/ Aged
/ alpha-Linolenic Acid - pharmacology
/ Biological and medical sciences
/ Cognitive Dysfunction - complications
/ DHA
/ Docosahexaenoic Acids - blood
/ Docosahexaenoic Acids - pharmacology
/ Eicosapentaenoic Acid - pharmacology
/ Elderly
/ EPA
/ Fundamental and applied biological sciences. Psychology
/ Gastroenterology and Hepatology
/ Humans
/ Psychology. Psychoanalysis. Psychiatry
/ Telomere Shortening - drug effects
/ Vertebrates: anatomy and physiology, studies on body, several organs or systems
