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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
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Journal Article
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
2007
Overview
Mitochondria are critically involved in necrotic cell death induced by Ca
2+
overload, hypoxia and oxidative damage. The mitochondrial permeability transition (MPT) pore — a protein complex that spans both the outer and inner mitochondrial membranes — is considered the mediator of this event and has been hypothesized to minimally consist of the voltage-dependent anion channel (Vdac) in the outer membrane, the adenine-nucleotide translocase (Ant) in the inner membrane and cyclophilin-D in the matrix
1
,
2
,
3
. Here, we report the effects of deletion of the three mammalian
Vdac
genes on mitochondrial-dependent cell death. Mitochondria from
Vdac1
-,
Vdac3
-, and
Vdac1
–
Vdac3
-null mice exhibited a Ca
2+
- and oxidative stress-induced MPT that was indistinguishable from wild-type mitochondria. Similarly, Ca
2+
- and oxidative-stress-induced MPT and cell death was unaltered, or even exacerbated, in fibroblasts lacking Vdac1, Vdac2, Vdac3, Vdac1–Vdac3 and Vdac1–Vdac2–Vdac3. Wild-type and
Vdac
-deficient mitochondria and cells also exhibited equivalent cytochrome
c
release, caspase cleavage and cell death in response to the pro-death Bcl-2 family members Bax and Bid. These results indicate that Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Hypoxia
/ letter
/ Mammals
/ Mice
/ Mitochondria, Heart - metabolism
/ Mitochondria, Liver - metabolism
/ Mitochondrial ADP, ATP Translocases - metabolism
/ Mitochondrial Membrane Transport Proteins - metabolism
/ Mitochondrial Membranes - metabolism
/ Mitochondrial Permeability Transition Pore
/ Mitochondrial Proteins - metabolism
/ Proto-Oncogene Proteins c-bcl-2
/ RNA, Small Interfering - genetics
/ RNA, Small Interfering - metabolism
/ Voltage-Dependent Anion Channel 1 - metabolism
/ Voltage-Dependent Anion Channel 2 - metabolism
/ Voltage-Dependent Anion Channels - deficiency
