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The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms
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Journal Article
The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms
2018
Overview
The planarian
Schmidtea mediterranea
is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of
S. mediterranea
, using long-read sequencing and a
de novo
assembler (MARVEL) enhanced for low-complexity reads. The
S. mediterranea
genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.
An improved genome assembly for
Schmidtea mediterranea
shows that the genome is highly polymorphic and repetitive, and lacks multiple genes encoding core components of cell biological mechanisms.
Genome of a regenerating worm
The flatworm
Schmidtea mediterranea
is an important model for regeneration. Jochen Rink, Eugene Myers and colleagues report an improved genome assembly for the planarian
S. mediterranea
using long-read sequencing and a new genome assembler called MARVEL. They find that the
S. mediterranea
genome is highly polymorphic and repetitive, and includes a novel class of giant retroelements. This improved genome assembly provides a useful resource for studying regeneration and the evolution of cell plasticity.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
