Journal Article

Metabolic Effects of Late Dinner in Healthy Volunteers—A Randomized Crossover Clinical Trial

Gu, Chenjuan, Jun, Jonathan C, Cotter, Matthew, Polotsky, Vsevolod Y, Pham, Luu V, Brereton, Nga, Schweitzer, Amy, Duan, Daisy, Børsheim, Elisabet, Wolfe, Robert R

2020

Overview

Abstract Context Consuming calories later in the day is associated with obesity and metabolic syndrome. We hypothesized that eating a late dinner alters substrate metabolism during sleep in a manner that promotes obesity. Objective The objective of this work is to examine the impact of late dinner on nocturnal metabolism in healthy volunteers. Design and Setting This is a randomized crossover trial of late dinner (LD, 22:00) vs routine dinner (RD, 18:00), with a fixed sleep period (23:00-07:00) in a laboratory setting. Participants Participants comprised 20 healthy volunteers (10 male, 10 female), age 26.0 ± 0.6 years, body mass index 23.2 ± 0.7 kg/m2, accustomed to a bedtime between 22:00 and 01:00. Interventions An isocaloric macronutrient diet was administered on both visits. Dinner (35% daily kcal, 50% carbohydrate, 35% fat) with an oral lipid tracer ([2H31] palmitate, 15 mg/kg) was given at 18:00 with RD and 22:00 with LD. Main Outcome Measures Measurements included nocturnal and next-morning hourly plasma glucose, insulin, triglycerides, free fatty acids (FFAs), cortisol, dietary fatty acid oxidation, and overnight polysomnography. Results LD caused a 4-hour shift in the postprandial period, overlapping with the sleep phase. Independent of this shift, the postprandial period following LD was characterized by higher glucose, a triglyceride peak delay, and lower FFA and dietary fatty acid oxidation. LD did not affect sleep architecture, but increased plasma cortisol. These metabolic changes were most pronounced in habitual earlier sleepers determined by actigraphy monitoring. Conclusion LD induces nocturnal glucose intolerance, and reduces fatty acid oxidation and mobilization, particularly in earlier sleepers. These effects might promote obesity if they recur chronically.

• Publisher: Oxford University Press,Copyright Oxford University Press
• Subject: Adolescent / Adult / Blood Glucose - analysis / Blood Glucose - metabolism / Body mass index / Clinical s / Clinical trials / Corticosteroids / Cross-Over Studies / Dextrose / Fatty acids / Fatty Acids, Nonesterified - blood / Fatty Acids, Nonesterified - metabolism / Feeding Behavior - physiology / Female / Glucose / Glucose Intolerance - blood / Glucose Intolerance - diagnosis / Glucose Intolerance - etiology / Glucose Intolerance - metabolism / Healthy Volunteers / Humans / Hydrocortisone - blood / Insulin - blood / Male / Meals - physiology / Obesity / Obesity - etiology / Obesity - metabolism / Obesity - physiopathology / Obesity - prevention & control / Oxidation-Reduction / Physiological aspects / Polysomnography / Sleep / Sleep - physiology / Time Factors / Triglycerides / Triglycerides - blood / Young Adult