Journal Article

Giant pedunculated cellular angiofibroma of the labia majora: a case report

Bafadni, Mudathir, Aagla, Khalid Abu

2026

Overview

Background Cellular angiofibroma is a rare, benign mesenchymal tumor most commonly arising in the vulvovaginal region in middle-aged to elderly women. Despite its indolent nature, it is frequently misdiagnosed due to a nonspecific clinical presentation and its resemblance to other vulvar masses. Case report We present a case of a 65-year-old postmenopausal woman with a neglected, slowly growing giant pedunculated mass on her left labia majora that developed over 5 years. The patient underwent surgical excision and cosmetic reconstruction, with an uneventful postoperative recovery. Histopathological examination confirmed a benign myxoid spindle cell neoplasm consistent with cellular angiofibroma. Discussion and conclusion This case highlights the challenges in the diagnosis of cellular angiofibroma owing to the tumor’s often nonspecific presentation and emphasizes the importance of surgical excision as the standard treatment, despite a low reported risk of recurrence even with positive surgical margins.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Aged / Angiofibroma - diagnosis / Angiofibroma - pathology / Angiofibroma - surgery / Asymptomatic / Blood vessels / Case Report / Case reports / Cellular angiofibroma / Connective tissue / Consent / Cysts / Family Medicine / Female / General Practice / Genital mesenchymal tumors / Humans / Immunohistochemistry / Internal Medicine / Literature reviews / Medicine / Medicine & Public Health / Postmenopausal women / Primary Care Medicine / Public Health / Surgical Oncology / Treatment Outcome / Tumors / Vulva / Vulva - pathology / Vulva - surgery / Vulvar Neoplasms - diagnosis / Vulvar Neoplasms - pathology / Vulvar Neoplasms - surgery