Asset Details
Do you wish to reserve the book?
Long non-coding RNAs as regulators of the endocrine system
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Long non-coding RNAs as regulators of the endocrine system
Do you wish to request the book?
Long non-coding RNAs as regulators of the endocrine system
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Long non-coding RNAs as regulators of the endocrine system
2015
Overview
Key Points
A substantial proportion of the genome is transcribed into non-coding RNAs, including many long non-coding RNAs (lncRNAs) that are important regulators of endocrine cells
Many research findings point towards an important role of lncRNAs in regulating the development and maintenance of endocrine organs and hormonal signalling; misregulation of these processes can lead to disease
The biological functions of lncRNAs in endocrine organs are poorly understood; genetic models are needed to fully assess the role of lncRNAs in a variety of homeostatic processes
in vivo
lncRNAs can be potentially developed as novel diagnostic markers to identify and classify certain tumours
Long non-coding RNAs (lncRNAs) have important roles in many physiological and pathological processes. The authors of this Review focus on the endocrine system and discuss the involvement of lncRNAs in the development and function of various endocrine organs, as well as the associations of lncRNAs with endocrine diseases such as diabetes mellitus and endocrine cancers.
Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often lineage-specific and that regulate multiple biological functions. Many are nuclear and are essential parts of ribonucleoprotein complexes that modify chromatin segments and establish active or repressive chromatin states; others are cytosolic and regulate the stability of mRNA or act as microRNA sponges. This Review summarizes the current knowledge of lncRNAs as regulators of the endocrine system, with a focus on the identification and mode of action of several endocrine-important lncRNAs. We highlight lncRNAs that have a role in the development and function of pancreatic β cells, white and brown adipose tissue, and other endocrine organs, and discuss the involvement of these molecules in endocrine dysfunction (for example, diabetes mellitus). We also address the associations of lncRNAs with nuclear receptors involved in major hormonal signalling pathways, such as estrogen and androgen receptors, and the relevance of these associations in certain endocrine cancers.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
