Journal Article

common brain network links development, aging, and vulnerability to disease

Walhovd, Kristine B., Johansen-Berg, Heidi, James, Anthony, Duff, Eugene P., Tamnes, Christian K., Westlye, Lars Tjelta, Gass, Achim, Fjell, Anders M., Monsch, Andreas U., Douaud, Gwenaëlle, Matthews, Paul M., Smith, Stephen M., Groves, Adrian R., Engvig, Andreas

2014

Overview

Significance Many evolutionary–developmental models have attempted to relate development and aging, with one popular hypothesis proposing that healthy age-related brain decline mirrors developmental maturation. But this elegant hypothesis has so far lacked clear and direct data to support it. Here, we describe intrinsic, entirely data-driven evidence that healthy brain degeneration and developmental process mirror one another in certain brain regions. Specifically, a data-driven decomposition of structural brain images in 484 healthy participants reveals a network of mainly higher-order regions that develop relatively late during adolescence, demonstrate accelerated degeneration in old age, and show heightened vulnerability to disorders that impact on brain structure during adolescence and aging. These results provide a fundamental link between development, aging, and disease processes in the brain. Several theories link processes of development and aging in humans. In neuroscience, one model posits for instance that healthy age-related brain degeneration mirrors development, with the areas of the brain thought to develop later also degenerating earlier. However, intrinsic evidence for such a link between healthy aging and development in brain structure remains elusive. Here, we show that a data-driven analysis of brain structural variation across 484 healthy participants (8–85 y) reveals a largely—but not only—transmodal network whose lifespan pattern of age-related change intrinsically supports this model of mirroring development and aging. We further demonstrate that this network of brain regions, which develops relatively late during adolescence and shows accelerated degeneration in old age compared with the rest of the brain, characterizes areas of heightened vulnerability to unhealthy developmental and aging processes, as exemplified by schizophrenia and Alzheimer’s disease, respectively. Specifically, this network, while derived solely from healthy subjects, spatially recapitulates the pattern of brain abnormalities observed in both schizophrenia and Alzheimer’s disease. This network is further associated in our large-scale healthy population with intellectual ability and episodic memory, whose impairment contributes to key symptoms of schizophrenia and Alzheimer’s disease. Taken together, our results suggest that the common spatial pattern of abnormalities observed in these two disorders, which emerge at opposite ends of the life spectrum, might be influenced by the timing of their separate and distinct pathological processes in disrupting healthy cerebral development and aging, respectively.

• Publisher: National Academy of Sciences,National Acad Sciences
• Subject: Adolescence / Adolescent / Adult / Age / Aged / Aged, 80 and over / Aging / Alzheimer Disease - physiopathology / Alzheimer's disease / Alzheimers disease / Behavioral neuroscience / Biological Sciences / Brain / Brain - pathology / Brain - physiology / Brain Mapping - methods / central nervous system diseases / Child / Developmental biology / Disorders / Female / Genetic Predisposition to Disease / Gray matter / Gray Matter - physiology / Humans / Magnetic Resonance Imaging / Male / Memory / Mental disorders / Middle Aged / Monte Carlo Method / Neurodegeneration / Pathology / Phylogeny / Schizophrenia / Schizophrenia - physiopathology / Software / Young Adult