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Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans
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Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans
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Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans
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Journal Article
Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans
2014
Overview
Significance Vaccination is the most effective means of attaining protection against influenza viruses. However, the constantly evolving nature of influenza viruses enables them to escape preexisting immune surveillance, and thus thwarts public health efforts to control influenza annual epidemics and occasional pandemics. One solution is to elicit antibodies directed against highly conserved epitopes, such as those within the stem region of influenza HA, the principal target of virus-neutralizing antibody responses. This study shows that annual influenza vaccines induce antibody responses that are largely directed against the highly variable HA head region. In contrast, heterologous immunization with HA derived from influenza strains that are currently not circulating in humans (e.g. H5N1) can substantially increase HA stem-specific responses.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Antibody Formation - immunology
/ Antibody Specificity - immunology
/ Cross Reactions - immunology
/ Epitopes
/ H5N1 subtype influenza A virus
/ Hemagglutinin Glycoproteins, Influenza Virus - chemistry
/ Hemagglutinin Glycoproteins, Influenza Virus - immunology
/ Humans
/ Influenza A Virus, H5N1 Subtype - immunology
/ Influenza Vaccines - immunology
/ Influenza, Human - immunology
/ Influenza, Human - prevention & control
/ Memory
/ Vaccines
/ Viruses
