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Prevalence and drug resistance of mycobacteria in Turkish cystic fibrosis patients
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Prevalence and drug resistance of mycobacteria in Turkish cystic fibrosis patients
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Journal Article
Prevalence and drug resistance of mycobacteria in Turkish cystic fibrosis patients
2014
Overview
Background
Isolation of mycobacteria in cystic fibrosis (CF) patients is increasingly being reported. Because of having long term antimicrobial treatment, CF patients are at risk of pulmonary infection with especially resistant nontuberculous mycobacteria (NTM) strains. The aim of the present study is to determine the prevalence of
mycobacterium
spp. and antimicrobial susceptibility in Turkish CF patients.
Methods
During a 5.5 year study period, 376 sputa from 130 CF patients were analyzed. Antimycobacterial susceptibility testing was performed by the Bactec 460 TB System and the E test method.
Results
Totaly 28 (7.44%)
Mycobacterium
spp. were isolated from eight (6.15%) CF patients. Five isolates (17.9%) were identified as
Mycobacterium tuberculosis
complex (MTBC), 14 (50%) as
Mycobacterium abscessus
and nine (32.1%) as
Mycobacterium lentiflavum
. All MTBC isolates were found to be susceptible to streptomycin, isoniazid, rifampicin, and ethambutol. Resistance to some antibiotics was detected in some NTM strains. These are the first data about the prevalence of mycobacteria in CF patients from Turkey.
Conclusions
In pediatric CF patients, specific mycobacterial analysis of sputum specimens and susceptibility testing should be performed for allowing early detection, identification and the possibility of eradication of these bacteria.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
Subject
/ Analysis
/ Antitubercular Agents - pharmacology
/ Biomedical and Life Sciences
/ Child
/ Cystic Fibrosis - complications
/ Drug resistance in microorganisms
/ Female
/ Humans
/ Male
/ Microbial Genetics and Genomics
/ Mycobacterium Infections, Nontuberculous - epidemiology
/ Mycobacterium Infections, Nontuberculous - microbiology
/ Mycobacterium tuberculosis - drug effects
/ Mycobacterium tuberculosis - isolation & purification
/ Nontuberculous Mycobacteria - drug effects
