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Classification of HHV-6A and HHV-6B as distinct viruses

by Gompels, Ursula A , Yoshikawa, Tetsushi , Lusso, Paolo , Dewhurst, Stephen , Yamanishi, Koichi , Jacobson, Steven , Höllsberg, Per , Agut, Henri , Ablashi, Dharam , Malnati, Mauro , Pellett, Philip E , Frenkel, Niza , Medveczky, Peter , Pritchett, Joshua C , Gallo, Robert , Clark, Duncan A , Luppi, Mario , Alvarez-Lafuente, Roberto , DiLuca, Dario , Flamand, Louis , Mori, Yasuko

in Acquired immune deficiency syndrome / AIDS / Biomedical and Life Sciences / Biomedicine / Brief Review / classification / Epidemiology / Genes / Genetic Variation / genetics / Herpes viruses / Herpesvirus 6, Human / Herpesvirus 6, Human - classification / Herpesvirus 6, Human - genetics / HIV / Human betaherpesvirus 6 / Human herpesvirus 6 / Human herpesvirus 6B / Human immunodeficiency virus / Humans / Immunology / Infections / Infectious Diseases / Medical Microbiology / Medicine / physicians / Roseolovirus Infections / Roseolovirus Infections - epidemiology / Roseolovirus Infections - immunology / Roseolovirus Infections - virology / scientists / taxonomy / Virology / viruses

2014

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Classification of HHV-6A and HHV-6B as distinct viruses

2014

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Classification of HHV-6A and HHV-6B as distinct viruses

2014

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Journal Article

Classification of HHV-6A and HHV-6B as distinct viruses

Gompels, Ursula A,

Yoshikawa, Tetsushi,

Lusso, Paolo,

Dewhurst, Stephen,

Yamanishi, Koichi,

Jacobson, Steven,

Höllsberg, Per,

Agut, Henri,

Ablashi, Dharam,

Malnati, Mauro,

Pellett, Philip E,

Frenkel, Niza,

Medveczky, Peter,

Pritchett, Joshua C,

Gallo, Robert,

Clark, Duncan A,

Luppi, Mario,

Alvarez-Lafuente, Roberto,

DiLuca, Dario,

Flamand, Louis,

Mori, Yasuko

2014

Overview

Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

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Publisher

Springer-Verlag,Springer Vienna,Springer Nature B.V

Subject

Acquired immune deficiency syndrome

/ AIDS

/ Biomedical and Life Sciences