Journal Article

Enhancing Drug Solubility, Bioavailability, and Targeted Therapeutic Applications through Magnetic Nanoparticles

Zhuo, Yue, Zhao, Yong-Gang, Zhang, Yun

2024

Overview

Biological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor solubility across varying physiological conditions often leads to reduced absorption and inconsistent therapeutic outcomes. This review examines how nanotechnology, especially through the use of nanomaterials and magnetic nanoparticles, offers innovative solutions to enhance drug solubility and bioavailability. This comprehensive review focuses on recent advancements and approaches in nanotechnology. We highlight both the successes and remaining challenges in this field, emphasizing the role of continued innovation. Future research should prioritize developing universal therapeutic solutions, conducting interdisciplinary research, and leveraging personalized nanomedicine to address biological variability.

• Publisher: MDPI AG,MDPI
• Subject: Animals / Apixaban / Bioavailability / Biological Availability / biological variability / drug absorption / Drug Carriers - chemistry / Drug Delivery Systems / Drug development / drug solubility / Drug therapy / Genetic engineering / Health aspects / Homeopathy / Humans / Influence / Innovations / Interdisciplinary research / Ivacaftor / magnetic nanoparticles / Magnetite Nanoparticles - chemistry / Magnetite Nanoparticles - therapeutic use / Materia medica and therapeutics / Metabolism / Nanomedicine - methods / Nanoparticles / Nanotechnology / Nanotechnology - methods / Patient safety / Pharmaceutical Preparations - chemistry / Pharmacokinetics / Physiology / Review / Side effects / Solubility / targeted drug delivery / Therapeutics