Asset Details
Do you wish to reserve the book?
Neural effects of methylphenidate and nicotine during smooth pursuit eye movements
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Neural effects of methylphenidate and nicotine during smooth pursuit eye movements
Do you wish to request the book?
Neural effects of methylphenidate and nicotine during smooth pursuit eye movements
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Neural effects of methylphenidate and nicotine during smooth pursuit eye movements
2016
Overview
Nicotine and methylphenidate are putative cognitive enhancers in healthy and patient populations. Although they stimulate different neurotransmitter systems, they have been shown to enhance performance on overlapping measures of attention. So far, there has been no direct comparison of the effects of these two stimulants on behavioural performance or brain function in healthy humans. Here, we directly compare the two compounds using a well-established oculomotor biomarker in order to explore common and distinct behavioural and neural effects.
Eighty-two healthy male non-smokers performed a smooth pursuit eye movement task while lying in an fMRI scanner. In a between-subjects, double-blind design, subjects either received placebo (placebo patch and capsule), nicotine (7mg nicotine patch and placebo capsule), or methylphenidate (placebo patch and 40mg methylphenidate capsule).
There were no significant drug effects on behavioural measures. At the neural level, methylphenidate elicited higher activation in left frontal eye field compared to nicotine, with an intermediate response under placebo.
The reduced activation of task-related regions under nicotine could be associated with more efficient neural processing, while increased hemodynamic response under methylphenidate is interpretable as enhanced processing of task-relevant networks. Together, these findings suggest dissociable neural effects of these putative cognitive enhancers.
•We investigated neural and behavioural effects of nicotine and methylphenidate in 82 healthy males•A smooth pursuit eye movement paradigm was used in fMRI to investigate performance and BOLD effects•There was no influence of either compound on behavioural measures of smooth pursuit•The methylphenidate group exhibited increased left frontal eye field activation in contrast to the nicotine group
Publisher
Elsevier Inc,Elsevier Limited
Subject
Attention deficit hyperactivity disorder
/ Central Nervous System Stimulants - administration & dosage
/ Dopamine
/ Dose-Response Relationship, Drug
/ Female
/ fMRI
/ Functional magnetic resonance imaging
/ Humans
/ Magnetic Resonance Imaging - methods
/ Male
/ Methylphenidate - administration & dosage
/ Motion Perception - drug effects
/ Motion Perception - physiology
/ Nicotine
/ Nicotine - administration & dosage
/ Nootropic Agents - administration & dosage
/ Psychomotor Performance - drug effects
/ Psychomotor Performance - physiology
/ Pursuit, Smooth - drug effects
/ Pursuit, Smooth - physiology
/ Smooth pursuit eye movements
/ Studies
