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Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses
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Journal Article
Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses
2012
Overview
Plant growth is coordinately regulated by environmental and hormonal signals. Brassinosteroid (BR) plays essential roles in growth regulation by light and temperature, but the interactions between BR and these environmental signals remain poorly understood at the molecular level. Here, we show that direct interaction between the dark- and heat-activated transcription factor phytochrome-interacting factor 4 (PIF4) and the BR-activated transcription factor BZR1 integrates the hormonal and environmental signals. BZR1 and PIF4 interact with each other
in vitro
and
in vivo
, bind to nearly 2,000 common target genes, and synergistically regulate many of these target genes, including the PRE family helix–loop–helix factors required for promoting cell elongation. Genetic analysis indicates that BZR1 and PIFs are interdependent in promoting cell elongation in response to BR, darkness or heat. These results show that the BZR1–PIF4 interaction controls a core transcription network, enabling plant growth co-regulation by the steroid and environmental signals.
Wang and colleagues have uncovered a direct functional relationship between the brassinosteroid-activated transcription factor BZR1 and the light- and heat-sensitive transcription factor PIF4. This interplay integrates hormonal and environmental signals to modulate cell elongation during plant growth.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Arabidopsis - growth & development
/ Arabidopsis - radiation effects
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Basic Helix-Loop-Helix Transcription Factors - genetics
/ Basic Helix-Loop-Helix Transcription Factors - metabolism
/ Biomedical and Life Sciences
/ Brassinosteroids - metabolism
/ Gene Expression Regulation, Plant
/ Gene-Environment Interaction
/ Genes
/ Hypocotyl - radiation effects
/ Kinases
/ Light
/ Nuclear Proteins - metabolism
/ Proteins
/ Steroids
