Journal Article

Exposure to Diesel Motor Exhaust and Lung Cancer Risk in a Pooled Analysis from Case-Control Studies in Europe and Canada

Wichmann, Heinz-Erich, Forastiere, Francesco, Gross, Isabelle M., Bueno-de-Mesquita, Bas, Pintos, Javier, Brüske, Irene, Dumitru, Rodica Stanescu, Vermeulen, Roel, Pohlabeln, Hermann, Bencko, Vladimir, Siemiatycki, Jack, Brüning, Thomas, Olsson, Ann C., Richiardi, Lorenzo, Lissowska, Jolanta, Janout, Vladimir, Consonni, Dario, Rudnai, Peter, Caporaso, Neil, Mirabelli, Dario, Merletti, Franco, Straif, Kurt, Stücker, Isabelle, Benhamou, Simone, Cassidy, Adrian, Fabianova, Eleonora, Ahrens, Wolfgang, Zaridze, David, Plato, Nils, Szeszenia-Dabrowska, Neonila, Landi, Maria Teresa, Kromhout, Hans, Foretova, Lenka, Brennan, Paul, Pesch, Beate, Boffetta, Paolo, Peters, Susan, Gustavsson, Per, Jöckel, Karl-Heinz, Kendzia, Benjamin

2011

Overview

Abstract Rationale Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure–response relationships. Objectives Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders. Methods The SYNERGY project pooled information on lifetime work histories and tobacco smoking from 13,304 cases and 16,282 controls from 11 case–control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure. Measurements and Main Results Odds ratios of lung cancer and 95% confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95% confidence interval, 1.19–1.43), and a significant exposure–response relationship (P value < 0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and never-smokers, although not statistically significant. Conclusions Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models and subgroup analyses.

• Publisher: Oxford University Press,American Thoracic Society
• Subject: Adult / Age Distribution / Aged / Canada - epidemiology / Carcinogens - toxicity / Case-Control Studies / Confidence Intervals / D. Environmental and Occupational Lung Disease/Lung Cancer and Oncologic Disorders / Diesel engines / Dose-response relationship / Europe - epidemiology / Female / Humans / Incidence / Logistic Models / Lung cancer / Lung Neoplasms - chemically induced / Lung Neoplasms - epidemiology / Lung Neoplasms - physiopathology / Male / Middle Aged / Occupational Exposure - adverse effects / Occupational Exposure - statistics & numerical data / Occupational Health / Odds Ratio / Reference Values / Risk Assessment / Severity of Illness Index / Sex Distribution / Smoking - adverse effects / Survival Analysis / Time Factors / Vehicle Emissions - toxicity