Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review

by Hegemann, Inga , Lassila, Riitta , Reding, Mark T. , Lissick, Jennifer , Ornstein, Deborah , Rangarajan, Savita , Fischer, Kathleen , Kempton, Christine , Cruz, Maria Sol , Byant, Paulette C. , Chitlur, Meera , de Raucourt, Emmauelle , Reid, Robin , Brown, Deborah , Laane, Edward , Mateo, Jose , Teitel, Jerry , Catarino, Cristina , Bonanad, Santiago , Dunn, Amy , Siragusa, Sergio , Turnstall, Oliver , Gottstein, Saskia , Thornburg, Courtney , de Cristofaro, Raimundo , Albert, Thilo , Hart, Daniel , Larson, Eric , Marco Vera, Pacual , Gruel, Yves , Yang, Renchi , Chowdary, Pratima , Cultrera, Dorina , Ozelo, Margarete , Pollio, Berardino , Beurrier, Philippe , Kruse‐Jarres, Rebecca , Cockrell, Erin , Tinmouth, Alan , Panetta, John Carl , Takemoto, Cliff , Faganel Kotnik, Barbara , Ramirez, Jose , Tosseto, Alberto , Primacakti, Fitri , James, Paula , Pouplard, Claire , Hermans, Cedric , Raffini, Leslie , Rodriguez Lopez, Manuel , Bidlingmaier, Cristoph , Selmeczi, Anna , Wilches Gutierrez, Juan D. , Zupan, Irena , Tapp, Heather , Desprez, Dominique , Streif, Werner , Cnossen, Marjon , Ahuja, Sanjay , Croteau, Stacy , P'Ng, Stephanie , Berrueco Moreno, Ruben , Sharathkum

in Children & youth / Cost control / drug substitution / factor IX / factor VIII / Hematology / Hemophilia / hemophilia A / hemophilia B / Hospitals / Online‐only / Patients / Pharmacokinetics / Population / Review / Studies

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review

2019

Confirm

Do you wish to request the book?

Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review

Hegemann, Inga,

Lassila, Riitta,

Reding, Mark T.,

Lissick, Jennifer,

Ornstein, Deborah,

Rangarajan, Savita,

Fischer, Kathleen,

Kempton, Christine,

Cruz, Maria Sol,

Byant, Paulette C.,

Chitlur, Meera,

de Raucourt, Emmauelle,

Reid, Robin,

Brown, Deborah,

Laane, Edward,

Mateo, Jose,

Teitel, Jerry,

Catarino, Cristina,

Bonanad, Santiago,

Dunn, Amy,

Siragusa, Sergio,

Turnstall, Oliver,

Gottstein, Saskia,

Thornburg, Courtney,

de Cristofaro, Raimundo,

Albert, Thilo,

Hart, Daniel,

Larson, Eric,

Marco Vera, Pacual,

Gruel, Yves,

Yang, Renchi,

Chowdary, Pratima,

Cultrera, Dorina,

Ozelo, Margarete,

Pollio, Berardino,

Beurrier, Philippe,

Kruse‐Jarres, Rebecca,

Cockrell, Erin,

Tinmouth, Alan,

Panetta, John Carl,

Takemoto, Cliff,

Faganel Kotnik, Barbara,

Ramirez, Jose,

Tosseto, Alberto,

Primacakti, Fitri,

James, Paula,

Pouplard, Claire,

Hermans, Cedric,

Raffini, Leslie,

Rodriguez Lopez, Manuel,

Bidlingmaier, Cristoph,

Selmeczi, Anna,

Wilches Gutierrez, Juan D.,

Zupan, Irena,

Tapp, Heather,

Desprez, Dominique,

Streif, Werner,

Cnossen, Marjon,

Ahuja, Sanjay,

Croteau, Stacy,

P'Ng, Stephanie,

Berrueco Moreno, Ruben,

Sharathkum

2019

Overview

The objective of this scoping review is to summarize the current use of pharmacokinetics for tailoring prophylaxis in hemophilia patients switching between clotting factor products. Patients with hemophilia may require switching of clotting factor concentrates due to a variety of factors, but there have been perceived risks associated with switching, such as inhibitor development or suboptimal protection due to inadequate dosing while titrating treatment. Studies that look at patients switching from one clotting factor concentrate to another are categorized in terms of their primary and/or secondary objectives, notably biosimilarity and comparative pharmacokinetic studies and inhibitor development studies. Research on how best to switch concentrates with respect to dosing regimen are lacking, and currently a trial‐and‐error approach is used for dosing the new factor concentrate. In the future, studies looking at the predictability of pharmacokinetics (PK) of a new factor concentrate based on individual PK knowledge of the original factor concentrate may offer clinical benefit by providing a safer switching approach and protocol.

Share this book

Add to My Shelf

Publisher

Elsevier Inc,Elsevier Limited,John Wiley and Sons Inc,Elsevier

Subject