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How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

by Caroline Stellmach , Maddalena Giannella , Surbhi Malhotra-Kumar , Dana Mates , Cédric Laouénan , Jan Hasenauer , Ruth Joanna Davis , Jesús Rodríguez-Baño , Paolo Boffetta , Eugenia Rinaldi , Laurence Meyer , Gabriella Scipione , Michael Hoelscher , Lorenzo Maria Canziani , Massimo Mirandola , Anna Maria Azzini , Evelina Tacconelli

in Antibodies / Cohort analysis / cohort study / cohort study; COVID-19; data harmonization; fragile population; healthcare workers; public health; vaccination / Communication / Complications / COVID-19 / COVID-19 vaccines / Data harmonization / Decision making / Epidemiology / Ethics / Fragile population / healthcare workers / Human medicine / Immunology / Infections / Medicine / Pandemics / Patients / Public health / R / Research methodology / Research projects / Risk factors / Serology / Severe acute respiratory syndrome coronavirus 2 / Subpopulations / Vaccination / Viral diseases

2023

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2023

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How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

2023

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Journal Article

How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

Caroline Stellmach,

Maddalena Giannella,

Surbhi Malhotra-Kumar,

Dana Mates,

Cédric Laouénan,

Jan Hasenauer,

Ruth Joanna Davis,

Jesús Rodríguez-Baño,

Paolo Boffetta,

Eugenia Rinaldi,

Laurence Meyer,

Gabriella Scipione,

Michael Hoelscher,

Lorenzo Maria Canziani,

Massimo Mirandola,

Anna Maria Azzini,

Evelina Tacconelli

2023

Overview

ORCHESTRA (“Connecting European Cohorts to Increase Common and Effective Response To SARS-CoV-2 Pandemic”) is an EU-funded project which aims to help rapidly advance the knowledge related to the prevention of the SARS-CoV-2 infection and the management of COVID-19 and its long-term sequelae. Here, we describe the early results of this project, focusing on the strengths of multiple, international, historical and prospective cohort studies and highlighting those results which are of potential relevance for vaccination strategies, such as the necessity of a vaccine booster dose after a primary vaccination course in hematologic cancer patients and in solid organ transplant recipients to elicit a higher antibody titer, and the protective effect of vaccination on severe COVID-19 clinical manifestation and on the emergence of post-COVID-19 conditions. Valuable data regarding epidemiological variations, risk factors of SARS-CoV-2 infection and its sequelae, and vaccination efficacy in different subpopulations can support further defining public health vaccination policies.

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Publisher

MDPI AG,MDPI

Subject

Antibodies

/ Cohort analysis

/ cohort study

/ cohort study; COVID-19; data harmonization; fragile population; healthcare workers; public health; vaccination

/ Communication

/ Complications

/ COVID-19