Asset Details
Do you wish to reserve the book?
Prophylactic effects of probiotic Bifidobacterium spp. in the resolution of inflammation in arthritic rats
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Prophylactic effects of probiotic Bifidobacterium spp. in the resolution of inflammation in arthritic rats
Do you wish to request the book?
Prophylactic effects of probiotic Bifidobacterium spp. in the resolution of inflammation in arthritic rats
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Prophylactic effects of probiotic Bifidobacterium spp. in the resolution of inflammation in arthritic rats
2019
Overview
In the present study, the modulatory effects of bifidobacterial spp. (
Bifidobacterium breve
NCIM 5671,
Bifidobacterium longum
NCIM 5672 and
Bifidobacterium bifidum
NCIM 5697) on adjuvant induced arthritis in rats were evaluated. Arthritis was induced in male Wistar rats by injecting 250 μg of Freund’s adjuvant directly into the paw. Fifteen days before and 15 days after the induction of arthritis, suspended cultures of bifidobacteria (10
9
cfu/ml) were administered by oral gavage. Paw volume, bone mineral content, oxidative stress markers, antioxidant enzymes, cytokines, eicosanoids and expression of COX2, as well as bone hydrolytic enzymes, were assessed by RT PCR. Although piroxicam-treated groups (drug control) had better effects than bifidobacteria-treated groups, bifidobacteria probiotics administration exhibited significant (
P
< 0.05) prophylactic effects in terms of downregulating arthritis markers. Parameters including paw volume, bone mineral content, cytokines, and eicosanoids level were significantly (
p
< 0.05) modulated in bifidobacteria administered groups compared to arthritic control group. Among the three strains tested,
B. breve
NCIM 5671 exhibited superior prophylactic effects as assessed in the experimental rat model of arthritis. In conclusion, bifidobacteria probiotics administration can downregulate the markers of arthritis and hence can be a potential therapeutic regimen in the treatment of arthritis.
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
