Journal Article

Health-related quality of life varies in different respiratory disorders: a multi-case control population based study

Marcon, Alessandro, Bombieri, Cristina, Sembeni, Silvia, Nicolis, Morena, Ferrari, Marcello, Cazzoletti, Lucia, Di Gennaro, Gianfranco, de Marco, Roberto, Cappa, Veronica, Zanolin, Maria Elisabetta, Perbellini, Luigi, Chamitava, Liliya, Spelta, Francesco

2019

Overview

Background and objective Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB). Methods Controls ( n  = 328) and cases of NAR ( n  = 95), AR ( n  = 163), CB ( n  = 48), CA ( n  = 224), PA ( n  = 126) and COPD ( n  = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. The relationships between HRQL (in terms of Physical (PCS) and Mental Component Scores (MCS)), respiratory diseases, and covariates were evaluated. Results With respect to controls, the adjusted PCS median score was worse in subjects suffering from current asthma (− 1.7; 95%CI:-2.8;-0.6), CB (− 3.8; 95%CI:-5.7;-1.9), and COPD (− 5.6; 95%CI:-8.1;-3.1). MCS was worse in current asthmatics (− 2.2; 95%CI:-4.1;-0.3), CB (− 5.5; 95%CI:-8.7;-2.2), and COPD cases (− 4.6; 95%CI:-8.8;-0.5) as well. Conclusions To our knowledge, this is the first study in the general population that analyzed HRQL performing a simultaneous comparison of HRLQ in several respiratory disorders. We found that subjects suffering from COPD, CA, and CB had the poorest HRQL. Clinicians should carefully consider the possible impact of respiratory disorders as CB and not only that of CA and COPD.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Allergies / Allergy / Asthma / Asthmatic persons / Bronchitis / Cancer / Chronic illnesses / Chronic obstructive lung disease / Chronic obstructive pulmonary disease / Clinical epidemiology / Complications and side effects / COPD / Critical Care Medicine / Epidemiology / Epidemiology and public health / Genetic research / Health maintenance organizations / Health surveys / Heart failure / HMOs / Intensive / Internal Medicine / Lung diseases / Medical research / Medicine / Medicine & Public Health / Palliative care / Pneumology/Respiratory System / Population / Population studies / Population-based studies / Prognosis / Public health / Pulmonology / Quality of life / Questionnaires / Research Article / Respiration / Respiratory diseases / Respiratory tract diseases / Rhinitis / Studies