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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
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Journal Article
Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
2013
Overview
HIV-1 entry into CD4⁺ target cells is mediated by cleaved envelope glycoprotein (Env) trimers that have been challenging to characterize structurally. Here, we describe the crystal structure at 4.7 angstroms of a soluble, cleaved Env trimer that is stabilized and antigenically near-native (termed the BG505 SOSIP. 664 gp140 trimer) in complex with a potent broadly neutralizing antibody, PGT122. The structure shows a prefusion state of gp41, the interaction between the component gp120 and gp41 subunits, and how a close association between the gp120 V1/V2/V3 loops stabilizes the trimer apex around the threefold axis. The complete epitope of PGT122 on the trimer involves gp120 V1, V3, and several surrounding glycans. This trimer structure advances our understanding of how Env functions and is presented to the immune system, and provides a blueprint for structure-based vaccine design.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Antibodies, Neutralizing - chemistry
/ Antibodies, Viral - chemistry
/ env Gene Products, Human Immunodeficiency Virus - chemistry
/ env Gene Products, Human Immunodeficiency Virus - immunology
/ Epitopes
/ Grants
/ HIV
/ HIV 1
/ HIV Envelope Protein gp120 - chemistry
/ HIV Envelope Protein gp120 - immunology
/ HIV Envelope Protein gp41 - chemistry
/ HIV Envelope Protein gp41 - immunology
/ Human immunodeficiency virus
/ Human immunodeficiency virus 1
/ Humans
/ mutation
/ Protein Structure, Quaternary
/ Recombinant Proteins - chemistry
/ Recombinant Proteins - immunology
/ Trimers
/ Vaccines
/ Viruses
